Transcranial Photobiomodulation

Fire! When you hold your hand near a fire, you feel its warmth. What's happening? The warmth you feel comes from the fire's infrared radiation, which your skin absorbs, stimulating your nerves to sense heat. Similarly, brain stimulation via transcranial photobiomodulation stimulates neuronal mitochondria, increasing cellular energy levels. This process modulates neuronal communication and brain waves by promoting neural synchronization and activity in targeted frequency ranges.

Alpha brainwaves represent the brain's resting state and are most prominent when your mind is meditative. These waves foster mental coordination, calmness, and inner peace. Alpha photobiomodulation can elevate neural alpha wave activity, enhancing relaxation and mental balance. In contrast, gamma brainwaves dominate when your mind is focused, attentive, and engaged in learning. They represent the brain's active state, where elevated gamma oscillations are associated with increased mental acuity and cognitive performance. Gamma photobiomodulation can boost neural gamma wave activity, supporting sharper focus and improved learning capabilities.

Sleep and Brain tailors photobiomodulation to optimize brain connectivity to ensure balanced neural network enhancement for cognitive and emotional well-being. We provide targeted neural stimulation by focusing on specific brain networks or comprehensive neural stimulation by engaging all networks simultaneously. In addition to standard alpha and gamma protocols, we utilize advanced features like cross-frequency coupling, frequency sweeps, and neural network synchronization.

We also use the Gracefire protocols, developed through years of neurofeedback-based research. The Gracefire protocols and adjustable module positions allow for precise targeting and programming. We customize session parameters, including session length, power intensity, phase asynchrony, duty cycle, and frequency pulses ranging from 1 to 40 Hz. We activate modules in various combinations, including synchronized patterns, enabling personalized programs that meet diverse cognitive and neurological needs. This customization level ensures optimized photobiomodulation for brain health goals.

At Sleep and Brain, we address the challenges of delivering near-infrared light energy (810–1100 nm) to the brain by overcoming obstacles like hair, scalp, and tissue. We use wavelengths within the body's optical window (800–1100 nm), which penetrate human tissue effectively. Among these, we focus on 810 nm, a wavelength with the lowest absorbance by tissue, blood, and water, making it ideal for brain stimulation. The 810 nm wavelength penetrates deeply, targeting mitochondria to boost adenosine triphosphate production, reduce oxidative stress, and regulate reactive oxygen species, enhancing cellular function. It also promotes neurogenesis, supporting the formation of new cortical neurons, while its anti-inflammatory properties reduce neuroinflammation and aid brain healing.

To ensure maximum energy delivery, we position the LEDs directly with the scalp, minimizing distance and preventing energy loss caused by the inverse square law of light. We also use advanced LED lens technology to bypass hair, which can be a significant barrier by trapping and absorbing light. By combining the optimal wavelength, direct LED-to-scalp contact, and hair-bypassing technology, we ensure effective and precise delivery of near-infrared red energy into the brain.

Achieving the optimal irradiance level is essential to ensure effective brain photobiomodulation. We use up to 400 mW/cm² of irradiance, the concentration of light energy delivered at the surface. Sufficient irradiance is critical for near-infrared light to penetrate the skin and skull. Higher irradiance allows for deeper penetration and better stimulation of brain tissue, supporting the activation of cellular processes and maximizing therapeutic benefits. Our system's irradiance ensures the light energy reaches the intended regions effectively, enabling superior outcomes for brain health while remaining within safe limits.

In addition to scalp sites, Sleep and Brain uses intranasal photobiomodulation to deliver near-infrared energy through the nose, targeting the brain's underside. This method directly stimulates the olfactory bulb, which connects to brain regions responsible for long-term memory storage and reaches the ventromedial prefrontal cortex, a key area for cognition.

At Sleep and Brain, we avoid using transcranial photobiomodulation helmets. Helmets fail to address hair as a barrier, with their inflexible dome shape causing significant energy loss through absorption by hair. They are also rigid and cannot adapt to different head sizes and shapes, increasing the distance between the light source and the scalp, which leads to rapid energy loss due to the inverse square law of light. Furthermore, helmets often rely on numerous weak LEDs, which generate high total power but insufficient irradiance, leaving the light energy too weak to penetrate the scalp effectively. Finally, helmets lack proper ventilation, leading to heat buildup, discomfort, and reduced practicality.

Frequently asked questions

What clinical studies support transcranial photobiomodulation for:

Dementia?

Cognitive Function:

Traumatic Brain Injury?

Parkinson’s Disease?

Anxiety and Depression?

Autism Spectrum Disorder?

Long Covid?

Brain Penetration?

Cellular Effects?

  • Wong-Riley MT, Liang HL, Eells JT, Chance B, Henry MM, Buchmann E, Kane M, Whelan HT. Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase. J Biol Chem. 2005 Feb 11;280(6):4761-71. doi: 10.1074/jbc.M409650200. Epub 2004 Nov 22. PMID: 15557336.

  • Liebert AD, Chow RT, Bicknell BT, Varigos E. Neuroprotective Effects Against POCD by Photobiomodulation: Evidence from Assembly/Disassembly of the Cytoskeleton. J Exp Neurosci. 2016 Feb 1;10:1-19. doi: 10.4137/JEN.S33444. PMID: 26848276; PMCID: PMC4737522.

  • Jou MJ, Jou SB, Guo MJ, Wu HY, Peng TI. Mitochondrial reactive oxygen species generation and calcium increase induced by visible light in astrocytes. Ann N Y Acad Sci. 2004 Apr;1011:45-56. doi: 10.1007/978-3-662-41088-2_5. PMID: 15126282.

  • Salehpour F, Mahmoudi J, Kamari F, Sadigh-Eteghad S, Rasta SH, Hamblin MR. Brain Photobiomodulation Therapy: a Narrative Review. Mol Neurobiol. 2018 Aug;55(8):6601-6636. doi: 10.1007/s12035-017-0852-4. Epub 2018 Jan 11. PMID: 29327206; PMCID: PMC6041198.

  • Moro C, Massri NE, Torres N, Ratel D, De Jaeger X, Chabrol C, Perraut F, Bourgerette A, Berger M, Purushothuman S, Johnstone D, Stone J, Mitrofanis J, Benabid AL. Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice. J Neurosurg. 2014 Mar;120(3):670-83. doi: 10.3171/2013.9.JNS13423. Epub 2013 Oct 25. PMID: 24160475.

How do you set up and operate the Vielight Neuro Pro 2?

What safety considerations should be taken into account?

  • Generally, healthy individuals should be able to use the device safely by limiting its use to 20 minutes.

  • Children can use this, but we start with 5-10 minutes and gradually extend; if headaches occur, reduce the duration.

  • You can share a unit with your partner but we recommend cleaning the nasal applicator with alcohol between uses, or you can purchase a separate applicator if preferred.

  • There have been no reported incidences of intranasal devices interfering with pacemakers.

  • Vielight technology is FDA registered under the Medical Specialty of Physical Medicine and is supported by our audited FDA QS820-compliant quality system. The FDA has also categorized the devices as low-risk general wellness devices by its draft "General Wellness: Policy on Low-Risk Devices," dated January 20, 2015. All Vielight devices have been independently TÜV certified as safe for consumer use.

How soon can I see improvements?

This varies on an individual basis. Some users have reported changes within a week. However, some have taken much longer to notice improvements in their general wellness.